Sensory mechanisms of TMD and orofacial pain

Sensory mechanisms of TMD and orofacial pain

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Barry J. Sessle, MDS, PhD, DSC (hon), FRsC, FCahs. Animal models of acute or chronic orofacial pain have revealed a vast array of ion channels, receptors, and chemical mediators involved in the peripheral sensitization of nociceptors following orofacial injury, thus pointing to potential biomarkers and targets for the development of new peripherally based approaches to help manage orofacial pain